News
Repligen Eyes Maravai Acquisition; Industry Shake-Up Looms
Repligen’s proposed merger with Maravai LifeSciences might redefine its prospects, and that of Maravai LifeSciences depending on market trends and pressures and financial performance.
United States – Repligen Corporation has offered to acquire Maravai LifeSciences Holdings with a market capitalization of almost USD 2. 5 billion. With Maravai set to have the biggest market problems, as its value reduced to 80% from August 2021, the proposal is in its darkest phase. According to insiders, Repligen is considering this option, but the Maravai’s willingness is still unknown.
Potential Restructuring and Asset Sales
Should the acquisition proceed, Repligen is considering restructuring Maravai and potentially divesting certain divisions. Discussions have also surfaced regarding the possible sale of Maravai’s nucleic acid production segment to private equity firms, including EQT AB. These developments are part of a broader strategy to reposition Maravai amid its declining market performance, as reported by Reuters.
Stock Market Reactions and Past Acquisition Attempts
Maravai’s stock surged by 20% following the announcement of the acquisition offer, while Repligen’s shares experienced a 12% decline, valuing the company at approximately USD 8 billion. This marks a significant shift in market dynamics. Previously, Maravai had turned down a USD 42 per share cash offer from Sartorius AG and more recently, a nonbinding proposal from Thomas H. Lee Partners.
Maravai’s Financial Struggles and Future Outlook
Maravai was incorporated roughly a decade ago and it saw its stock really take off during the COVID-19 vaccine frenzy, though it has since struggled to expand beyond mRNA vaccines. The company recently ratcheted down its outlook for revenue in the year ending March 2024 to a range that is USD265-285 million below prior-year levels. Their last financial statements showed a loss and a greater loss in earnings per share than estimated.
Understanding Repligen’s Background and Industry Role
Repligen was founded in 1981 and the company is focused on the creation of instruments and devices involved in drug-making for key pharmaceutical companies and CDMOs around the world. A number of innovative techniques offered by the company are essential in the pharmaceutical sector, as reported by Reuters.
News
Bridging the Gap: Police Training for Black Autistic Youth
Improved police training and awareness are essential to ensure safer, more understanding interactions with Black autistic youth.
United States: Black parents with teenagers with autism have concerns about their children’s vulnerability when they encounter police officers.
Key Findings from the Study
A study published on Dec. 16 in the Autism Journal has revealed that aspects like reduced eye contact observed in children with autism may make police consider them to be guilty, as reported by HealthDay.
Sadly, police officers do not learn that these actions are typical among children with autism, families informed scholars.
Voices of the Researchers
“It’s important for everyone to understand that the parents in this study said they were hopeful, which we interpreted as Black caregivers’ faith that interactions between officers and Black autistic youth could be better,” said lead researcher Ashlee Yates Flanagan, a clinical psychologist at the Children’s Hospital of Philadelphia Center (CHOP) for Autism Research.
Researchers reveal important themes to improve interactions between police and Black autistic youth https://t.co/4KaqLTKU8M
— Continental Clinical (@Conti_Clinical) December 16, 2024
“This demonstrates that there’s space for improvement in training, and we can take what we know from this study and explore it further,” Flanagan added in a CHOP news release.
During the interviews, four distinct themes surfaced:
- The caliber of police officer education
- Inappropriate police enforcement of typical autistic behaviors
- The overt threat of injury and death
- Families believe that police officers may become aggressive towards gestures and responses that are normal for AS children but not for other children, as the study indicated.
Some families said that training might make police see these differences in conduct, which should bring about tolerance and perseverance that could enhance the relations between children and the police.
CHOP Researchers Identify Key Ways to Improve Police Interactions with Black Autistic Youthhttps://t.co/8wlvNa0HUu pic.twitter.com/RhpNeYSc0f
— Autism and Friends (@autismtalknd) December 17, 2024
“In this study, we captured rich narratives from stakeholders who have not been represented well in prior research, but whose thoughts and perspectives are critical for knowing how to improve outcomes for Black autistic youth and police,” said senior researcher Julia Parish-Morris, a scientist in the CHOP Center for Autism Research, as reported by HealthDay.
“Our findings suggest that there is a lot of room for growth in training for police officers and that Black parents of Black autistic youth carry hope that outcomes can be improved,” Parish-Morris added.
News
AI Breakthrough Simplifies Lung Disease Testing
This AI breakthrough promises faster, more accessible, and cost-effective COPD diagnosis with a single CT scan.
United States: Research says that people with breathing problems can know whether they are suffering from COPD with the help of a new lung AI test.
AI Offers a One-Scan Solution for COPD
The newly developed AI can accurately diagnose COPD using data from a single chest CT scan performed as a person inhales, researchers reported Dec. 12 in the journal Radiology: Cardiothoracic Imaging, as reported by HealthDay.
The researchers said it can also inform from that scan how severe a person’s COPD is.
So far, doctors have required two CT scans to diagnose and assess COPD — one when the person has taken a deep breath and one when he or she has exhaled.
“Our study shows that COPD diagnosis and staging is feasible with a single CT acquisition and relevant clinical data,” said researcher Kyle Hasenstab, an assistant statistics and data science professor at San Diego State University.
A Growing Global Health Concern
COPD is defined as a systemic group of lung diseases that become worse over time and make it difficult for individuals in the community to breathe. COPD is chronic, and there is no known treatment for the disease, although it ranks third in deaths globally, according to the researchers’ background information.
The researchers added that spirometry, a lung function test that tests the amount of air, including vital capacity, that a patient can inhale and exhale, has been the primary approach toward identifying COPD.
Some hospitals already use CT images of the lungs to help diagnose COPD because the images can point out lung tissue that might be limiting breath, Hasenstab said.
“However, this type of protocol is not clinically standard across institutions,” Hasenstab said; this is due to the fact that it requires additional training for the staff to be able to take good CT images as well as to be able to interpret them.
Scientists believed that if the AI could read CT scans for COPD, more people could be provided with CT scans, despite a lack of training.
How the AI Works
To provide answers for this study, the researchers captured the inhaled and expelled lung CT scans of nearly 8,900 patients who were tested from November 2007 to April 2011 and their spirometry results.
The average age of patients was 59, and all patients were smokers.
Benefits of the AI Tool
The team then utilized the CT scans and the clinical data to teach the AI to forecast spirometry outcomes.
Study findings indicated that the AI could identify COPD by relying on one of the CT scans and could reasonably express how severe the COPD had become.
Researchers pointed out that when they introduced clinical data, the accuracy of the AI was enhanced.
Researchers also discovered that the AI’s performance was similar when the patients had to hold their breath during the CT scan or when they were breathing normally, as reported by HealthDay.
“Reduction to a single inspiratory CT acquisition can increase accessibility to this diagnostic approach while reducing patient cost, discomfort, and exposure to ionizing radiation,” Hasenstab said in a journal news release.
News
Screen Time Wrecks Preschoolers’ Sleep and Behavior
Excessive screen time disrupts preschoolers’ sleep and behavior, underscoring the need for controlled device usage and better sleep habits.
United States: Excessive use of electronic devices threatens preschoolers’ sleep and urges the child to become a terror of the house, new research shows.
Screen Time and Sleep: A Vicious Cycle
Researchers said poor sleep worsens children’s ability to focus and be less hyperactive and moody, as published in Early Child Development and Care on 12th December.
Worse still, cylinders can occur where kids spend a lot of time in front of screens, leading to poor sleeping habits and consequently increased screen time, as reported hy HealthDay.
“Our results suggest the presence of a positive feedback loop, wherein increased screen time and sleep disturbances exacerbate each other through cyclic reinforcement, heightening the risk of hyperactive attention problems, anxiety, and depression,” said researcher Dr. Bowen Xiao, an expert in children’s socio-emotional functioning and developmental psychopathology with Carleton University in Canada.
The Research: Insights from Parents
To gather data, the authors administered questionnaires to the 571 mothers of preschool children aged between 3 and 6 years attending seven public kindergartens in Shanghai.
Moms recorded the number of daily hours their children spent with a TV, smartphone, computer, or any other screen-based device. They also asked them questions to determine any possible behavioral issues that their kids may have, as well as the quality and duration of sleep their children get.
“Our results indicate that excessive screen time can leave the brains of preschool children in an excited state, leading to poor sleep quality and duration,” said researcher Yan Li, an expert in preschool education from Shanghai Normal University.
Researchers also pointed out that other studies have shown that children’s screen use can cause emotional issues and hyperactivity.
According to this study, screen time may be the cause, according to the experts.
Screen Time’s Impact on Sleep
“This poor sleep may be due to postponed bedtimes caused by screen viewing and the disruption of sleep patterns due to overstimulation and blue-light exposure,” added lead author Shujin Zhou, a doctor of psychology at Shanghai Normal University.
“Screen use might also displace time that could have been spent sleeping and increase levels of physiological and psychological arousal, leading to difficulties in falling asleep,” Zhou said in a journal news release.
Therapeutic Implications
According to Zhou, these findings may help guide future therapies for young children’s mood and hyperactivity issues.
“The implications of our study are two-fold: first, controlling screen use in preschool-age children can help alleviate behavioral problems and poor sleep quality, and second, sleep interventions and treatments can be effective in mitigating the adverse effects of screen time on behavioral issues,” Zhou noted, as reported hy HealthDay.
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