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Recent Climate Records Shattered, Here’s What Happened

Global temperatures are rising at intimidating rates, surpassing records month after month, emphasizing the critical need for nippy action to alleviate climate change impacts

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United States :The world’s temperatures are rising month after month to new heights. Scientists and climate policy experts advise that there’s adding chance that global warming may surpass the major Paris 2015 climate agreement.

For some, making sense of the recent spate of climate extremes may prove difficult. Check out what scientists have to say about this.

What are the climates records have broken recently?

Last month, the climate monitoring organization for the European Union, Copernicus, declared that May was the hottest on record, a record that has been broken for 12 consecutive months. at a separate assessment, the World Meteorological Organization calculated that there is nearly a twofold probability that average global temperatures from 2024 to 2028 will exceed the 1.5 degrees Celsius (2.7 degrees Fahrenheit) warming target since pre-industrial times that was agreed upon at the Paris climate conference.

And here’s another: 57 scientists found that Earth warmed somewhat quicker in 2023 than in 2022 in a paper published in the journal Earth System Science Data.

Are climate scientist surprised?

Not really. Numerous climate scientists claim that warming trends are in line with their exploration and prognostications on the accumulation of carbon dioxide performing from increased operation of fossil energies.

According to the U.S. National Oceanic and Atmospheric Administration, the attention of certain heat- enmeshing feasts in the atmosphere hit record highs in 2023. According to NOAA, the quantum of hothouse feasts created by mortal exertion — of which carbon dioxide is the most current and significant — rose by the third-loftiest position in 65 times in 2023.

What so the shattered records mean for humans?

More pain. Unpredictable storms, extreme weather fluctuations, and heat waves that linger over a region for extended periods of time are all results of human-caused climate change.

This spring, an Asian heat wave killed people in Thailand, set records in Indonesia, Malaysia, the Maldives, and Myanmar, and caused the closure of schools in the Philippines. Last month, weeks-long heat waves that affected many parts of India also caused school closures and fatalities.

Scientists predict that while life won’t cease if temperatures rise above the 1.5-degree mark, things will grow worse. According to earlier U.N. studies, global warming of 1.5 to 2 degrees Celsius is more likely to cause drastic changes in Earth’s ecosystem, including the eventual loss of the planet’s coral reefs, Arctic sea ice, and some plant and animal species. Extreme weather events that cause fatalities and damage to infrastructure are also likely to occur.

What can be done?

Climate scientists that are always there to help with the worst effects of climate change, the usage of fossil fuels must be phased out. The primary cause of global warming brought on human by the human activity is the combustion of fossil fuels, such as coal, gas and oil.

Francis predicted that “we will keep breaking temperature records, along with increasingly frequent and intense extreme weather events, until greenhouse gas concentrations level off.”

Although it has been developing quickly, renewable energy still needs to grow much quicker. Although efficiency is being researched, developed, and implemented throughout the economy—in the ways we cook our food, heat our homes and buildings, and manufacture cement, for example—scientists argue that adaptation is important.

There are several private foundations that provide financial assistance for the Associated Press’s coverage of climate change and biodiversity. All content is the exclusive responsibility of AP. Visit AP.org to view AP’s guidelines for collaborating with philanthropies, a list of supporters, and supported coverage areas.

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From Weight Loss to Liver Healing: Semaglutide Shines Again 

Semaglutide, the active ingredient in Ozempic and Wegovy, has shown promising results in treating MASH—a severe form of fatty liver disease. 

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Photo: (Aprott/iStock/Getty Images Plus)

Semaglutide, already a celebrated compound in renowned medications like Ozempic and Wegovy, has now unveiled another dimension of its healing prowess—this time targeting an aggressive liver affliction. A sweeping international research endeavor has brought to light its potent influence on a condition known as Metabolic Dysfunction-Associated Steatohepatitis (MASH), a severe variation of fatty liver disease. 

Spanning across 72 weeks and engaging 800 participants from 37 countries, this phase 3 clinical voyage unraveled transformative effects. Individuals who were administered weekly semaglutide doses displayed substantial reversal in MASH symptoms, with nearly two-thirds reflecting clinical improvement. 

“This expansive investigation underscores semaglutide’s power—not just in mending liver tissue, but in alleviating the tangled metabolic roots of the disease,” shared Arun Sanyal, distinguished medicine professor at Virginia Commonwealth University, according to sciencealert.com. 

Participants were segmented into treatment and placebo brackets. Among those receiving semaglutide, 62.9 percent manifested marked improvement in MASH-related symptoms. In stark contrast, only 34.3 percent of the placebo group showed comparable results. 

Further bolstering its therapeutic profile, semaglutide also contributed to a significant easing of liver fibrosis—essentially scarring caused as the liver attempts self-repair. In this regard, 36.8 percent of medicated individuals saw reduction in fibrosis severity, whereas only 22.4 percent of placebo recipients noticed such change. 

A dual benefit—amelioration in both MASH and fibrosis—was witnessed in 32.7 percent of patients under semaglutide, doubling the 16.1 percent seen in the control group. This outcome not only reinforces semaglutide’s multifaceted influence but also paves the way for a broader medical horizon. 

The placebo response, often attributed to psychological uplift and heightened lifestyle mindfulness during trials, remained consistent with typical trends. 

“If this therapy gains formal sanction, it could stand as an essential addition for patients grappling with MASH and its hepatic scarring,” noted Sanyal. 

The gravity of this prospect lies in MASH’s tight linkage with heart disease, diabetes, and kidney disorders—all arenas where semaglutide has already carved a track record of success, as per sciencealert.com. 

Functionally, semaglutide acts as a GLP-1 receptor agonist—a mimic of the body’s natural hormone responsible for appetite suppression and blood glucose moderation. Though it was initially prized for combating obesity and type 2 diabetes, its biological fine-tuning capabilities seem to unlock broader therapeutic doors. 

In the realm of liver diseases, experts speculate semaglutide’s modulation of metabolic and inflammation pathways strikes at the very nucleus of MASH progression. 

While this phase has concluded, the study marches onward, extending its reach to a more expansive population over a five-year timeline to gauge durability of these initial strides. Currently, with only a single recognized treatment for MASH on the market, such breakthroughs carry urgent weight. 

“By addressing both hepatic impairment and its metabolic undercurrents, semaglutide symbolizes a paradigm shift in treatment—offering a glimmer of hope to millions who endure in silence,” concluded Sanyal, according to sciencealert.com. 

The detailed findings have now found a home in the pages of the New England Journal of Medicine. 

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Clock Ticking: US Rushes for Universal Bird Flu Vaccine by 2029 

The US Department of Health and Human Services has launched an ambitious initiative to develop a universal flu vaccine within four years. 

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United States: In a sweeping scientific endeavor unmatched in nearly half a century, the US Department of Health and Human Services (HHS) declared its mission to fabricate a universal influenza inoculation within the next four years—one that could outmaneuver numerous mutating viral strains, including the highly pathogenic H5N1 avian flu. 

“This is not incremental—it’s a cataclysmic recalibration,” stated Dr. Jay Bhattacharya, Director of the National Institutes of Health, as he unveiled the transformative project, Generation Gold Standard. “This isn’t just about today’s viral shadows—it’s about preempting tomorrow’s contagions using reimagined conventional vaccine craft.” 

Hatched within the corridors of the National Institute of Allergy and Infectious Diseases, the plan has its sights set on gaining FDA sanction for a pan-influenza vaccine by 2029. Human trials are penciled in for next year. The initial disclosure came via The Wall Street Journal, confirming that the initiative would be underpinned by a $500 million infusion from the Biomedical Advanced Research and Development Authority, a figure corroborated by HHS spokespeople, according to CNN. 

“I want this to succeed,” offered Dr. Paul Offit of the Children’s Hospital of Philadelphia, a veteran of influenza vaccine research. “This field isn’t barren from apathy nor drained of brilliance or funds. It’s simply an enormous biological conundrum.” 

Influenza viruses mutate with a capriciousness that has continually outpaced all-encompassing immunization. As a result, the populace is prodded each year with revised formulations tailored to prevailing strains. 

HHS’s gambit echoes its similar ambition in the COVID-19 sphere: to birth a universal coronavirus vaccine that shields not just against SARS-CoV-2, but its ominous kin, SARS-CoV-1 and MERS-CoV. 

An Audacious Leap with Anachronistic Tools 

Ironically, the engine of this cutting-edge aspiration is an old-school vaccine strategy: inactivated whole-virus methodology. Here, pathogens are chemically muted to prevent infection but still provoke an immune response. This strand of research is helmed by Dr. Matthew Memoli and Dr. Jeffery Taubenberger at NIH. 

Dr. Memoli, who courted headlines in 2021 for rebuffing COVID vaccine mandates and declining the jab himself, described one candidate nasal vaccine as “an immune simulator, echoing the body’s response to an authentic flu invasion,” as per reports by CNN. 

External experts—though applauding the vision—have voiced skepticism about feasibility. 

Dr. Greg Poland of the Mayo Clinic delineated the scientific gold standard: a universal flu jab should grant at least 75% protection against both A and B strains for a full year or more across all age brackets. However, Poland critiqued the project’s top contender, BPL-1357, for only containing A-strain variants. “This suggests they’re eyeing potential pandemic instigators, not the seasonal usual suspects,” he surmised. 

Poland also bristled at the decision to bet big on a vaccine archetype largely shelved by modern virology. “It feels like constructing a spacecraft with blueprints from the Wright brothers,” he mused. 

While whole-virus formulations deliver multi-pronged immune training, their broad exposure can boomerang, triggering excessive immune reactions or adverse events. Such vaccines are often cultivated in egg or cell mediums—this initiative uses canine kidney cells. Viruses are chemically disarmed using beta-propiolactone before being packaged into injections or nasal sprays. 

Historically, the US pivoted from these inactivated whole-virus methods to subtler options—like split-virus or subunit vaccines. Some nations, however, still employ the full-virus strategy, according to CNN. 

Dr. Peter Hotez from Texas Children’s Hospital warned of history repeating. He invoked the 1976 swine flu debacle when a robust vaccine reaction led to a surge in Guillain-Barré syndrome. Hotez labeled whole-virus methods “highly reactogenic,” underscoring their propensity to overstimulate the immune system. 

“It’s baffling why they’re doubling down on such a volatile platform,” Hotez confessed. 

Revamping the Rules of Vaccine Approval 

On the eve of its universal vaccine pronouncement, HHS quietly dropped a regulatory bombshell: henceforth, all new vaccines must undergo rigorous placebo-controlled trials before greenlighting. A seismic deviation from norms, this shift could bottleneck annual COVID shot rollouts. 

Previously, the FDA emulated its flu model—only updating strains within the vaccine and skipping full trials. This strategy fast-tracked annual boosters aligned with dominant strains. 

Dr. Offit noted, “Changing the strain gives us sharper antibody defenses for a few months—crucial for the elderly and frail.” Delays from mandatory trials could jeopardize vulnerable lives during flu and COVID seasons, according to CNN. 

Though HHS hasn’t clarified if this edict applies to updated COVID jabs, one official told CNN it was about reinstating gold-standard science for newer mRNA-based vaccines, distinguishing them from long-tested flu inoculations. 

Confusion deepened when the FDA missed its April 1 decision deadline for full approval of Novavax’s non-mRNA COVID vaccine. The company later disclosed that the FDA had requested post-approval clinical trials, signaling a possible precedent for future vaccines, including updates from Moderna and Pfizer. 

Moderna, in a recent investor call, downplayed concerns, assuring it was “business as usual.” However, uncertainty looms over whether the FDA concurs. Decisions on Moderna’s next-gen COVID vaccine and RSV expansion are expected by late May and June, respectively. Approval for its combined flu-COVID jab has been pushed to 2026, pending more data. 

The firm also announced it would pull back from developing combo vaccines for those under 50, pivoting towards oncology and elder care. 

A Shifting Landscape and Growing Tensions 

If the FDA locks in this new trial standard, it marks a philosophical U-turn. “They had adopted a flu-style model for COVID boosters. Now they’re unraveling it,” noted Dorit Reiss, a law professor at UC Law San Francisco, as per CNN. 

The FDA has already penciled in a May 22 meeting to discuss which COVID strains should feature in the next vaccine cycle. 

HHS didn’t stop at trials. It also lambasted current vaccine safety surveillance tools—like VAERS and the Vaccine Safety Datalink—as outdated and ineffective. The agency vowed to construct new systems to better track vaccine benefits and harms. 

This contradicts a commitment Secretary Robert F. Kennedy Jr. allegedly made to Sen. Bill Cassidy in February: to avoid creating parallel monitoring infrastructures. 

Sen. Cassidy, a physician and Republican, reiterated his backing for universal vaccines, calling them the “Holy Grail” against fast-mutating foes. But he cautioned against overhauling approval systems for updated shots: “If the original vaccine has proven safe, we shouldn’t withhold access just to fulfill trial quotas.” 

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New Discovery: 5 Blood Proteins Could Foreshadow Liver Illness Over a Decade Early 

A study pinpoints five elusive blood proteins that can flag severe liver illness up to 16 years before symptoms strike, offering a chance of prolonged health. 

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Forecasting ailments long before their grip tightens could shift the medical realm from reactive to preventative. A group of researchers has spotlighted five subtle yet potent blood proteins capable of forewarning an individual’s odds of enduring an advanced liver malady—well over a decade before it manifests. These transformative revelations, slated for unveiling at Digestive Disease Week (DDW) 2025, unlock avenues for swifter detection, swifter actions, and, perhaps, superior outcomes. 

Silent Surge of MASLD 

This research zeroes in on metabolic dysfunction-associated steatotic liver disease (MASLD), a silent epidemic now reigning as the foremost liver disease worldwide. The frequency of MASLD continues to swell, dragging along a fatality risk that towers nearly twofold over those untouched by it. 

Whispers from Within: The Biomarker Breakthrough 

“Picture having foresight into MASLD’s threat long before it stirs,” shared Dr. Shiyi Yu, a resident in gastroenterology at Guangdong Provincial People’s Hospital, China. “Most only recognize liver peril after it clenches tight. There’s a dire craving for reliable biomarkers and forecasting blueprints. Our endeavor uncovers plasma proteins as harbingers of hope,” according to SciTechDaily.com. 

Drilling into over 50,000 blood specimens from the UK Biobank and tracing participants for 16+ years, researchers scrutinized over 2,700 distinct proteins. From this biological sea, five proteins surfaced as early harbingers: CDHR2, FUOM, KRT18, ACY1, and GGT1—biochemical whispers of liver calamity to come. 

Numbers That Speak Volumes 

This protein ensemble demonstrated a startling foresight: an 83.8 percent predictive edge five years out, tapering only slightly to 75.6 percent at the 16-year mark. When meshed with day-to-day markers like body mass and physical movement, the model’s accuracy surged—hitting 90.4 percent at five years and 82.2 percent across sixteen. 

Dr. Yu added, “Our model echoed its precision in an entirely different group in China, underscoring its resilience and broad applicability,” as per SciTechDaily.com. 

Still Waters Run Deep 

Despite its brilliance, the study remains observational—it detects links, not causes. But with pathways still being explored, this discovery ushers in a fresh frontier, where blood murmurs truths long before pain speaks. 

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