News
Male Birth Control Gel Proves Effective in Recent Trial
A novel hormone gel shows promise as a fast-acting, effective male birth control method amid growing interest and ongoing research.
United States: Researchers revealed on Sunday that a novel hormone gel may eventually be used by males as a method of birth control, though recently in America the interest in male birth control has increased drastically and also the researchers are hopeful about this new method.
Study Highlights
In a news release announcing findings that were presented on Sunday at the Endocrine Society’s annual meeting in Boston, senior study author Diana Blithe, chief of the Contraceptive Development Program at the National Institutes of Health, stated that “the development of a safe, highly effective, and reliably reversible contraceptive method for men is an unmet need.”
How It Works
222 men used a teaspoon-sized amount of gel (5 millilitres) administered once daily to each shoulder blade in the phase 2 experiment.
As a consequence, 86% of the males experienced sperm suppression. It was faster than anticipated that the average timing for effective contraceptive was eight weeks.
“The gradual onset of spermatogenic suppression [has been] a limitation, even though studies have suggested that certain hormonal agents may be useful for male contraception,” Blithe said.
However, she clarified, this gel acts more rapidly and requires less testosterone because it contains both testosterone and Nestorone, a synthetic hormone already present in the vaginal contraceptive ring.
Research Insights
Blithe continued, “Previous research on injectable male hormonal contraceptives indicated a median time of 9 to 15 weeks for sperm output to become suppressed.”
According to Blithe, “a faster time to suppression may increase this drug’s attractiveness and acceptability to potential users.”
Researchers are now tracking how well the gel works and also the male volunteers should be committed in monogamous relationship and they need consent from their female partner. The couple must agree to use the gel as their only birth control and to have sex at least once a. month for a year, this data is reported by NBC, and throughout the study, men will have their sperm counts tested periodically.
Daniel Johnston, head of the Contraception Research Branch of the National Institute of Child Health and Human Development, told NBC News, “We’ve been pushing for hormonal male contraceptives for 50 years, but there isn’t enough money available to really drive something through a very large phase 3 trial.”
Challenges and Future Steps
Pharmaceutical companies might invest more on comparable drugs, though, if the U.S. Food and Drug Administration authorized a single male birth control pill, according to Johnston.
Johnston said, “We’ve been chasing this for a long time.” “Hopefully, we’re breaking new ground.”
Additional Developments
During the Boston meeting, YourChoice Therapeutics also revealed that their non-hormonal tablet, YCT-529, was safe and had no side effects, based on a very tiny British trial that included just 16 men. The medication made by the San Francisco business functions are blocking the vitamin A receptors which are important for the male fertility.
Since the Supreme Court repealed Roe v. Wade in June 2022, interest in male birth control has increased, according to Heather Vahdat, executive director of the Male Contraceptive Initiative.
Following the court’s ruling, a significant rise was observed in the number of young women and men selecting permanent birth control methods including vasectomy and tubal ligation, according to recent data from the University of Pittsburgh School of Public Health.
Growing Interest
According to a different survey, which was partially carried out by the Male Contraceptive Initiative, 78% of American men expressed interest in trying new birth control methods prior to the abortion verdict. It then increased to 82%.
Vahdat stated, “The demand has always existed, but it’s now more intense.” People frequently email us to inquire about their whereabouts.
The new methods of contraception are designed to be reversible, unlike vasectomy, allowing men to resume their ability to bear children if they so choose.
When worn correctly, condoms can be quite efficient in preventing pregnancy and STDs, but this is difficult to accomplish. According to Bakshi, they are also not the recommended method of contraception in committed partnerships.
News
Bridging the Gap: Police Training for Black Autistic Youth
Improved police training and awareness are essential to ensure safer, more understanding interactions with Black autistic youth.
United States: Black parents with teenagers with autism have concerns about their children’s vulnerability when they encounter police officers.
Key Findings from the Study
A study published on Dec. 16 in the Autism Journal has revealed that aspects like reduced eye contact observed in children with autism may make police consider them to be guilty, as reported by HealthDay.
Sadly, police officers do not learn that these actions are typical among children with autism, families informed scholars.
Voices of the Researchers
“It’s important for everyone to understand that the parents in this study said they were hopeful, which we interpreted as Black caregivers’ faith that interactions between officers and Black autistic youth could be better,” said lead researcher Ashlee Yates Flanagan, a clinical psychologist at the Children’s Hospital of Philadelphia Center (CHOP) for Autism Research.
Researchers reveal important themes to improve interactions between police and Black autistic youth https://t.co/4KaqLTKU8M
— Continental Clinical (@Conti_Clinical) December 16, 2024
“This demonstrates that there’s space for improvement in training, and we can take what we know from this study and explore it further,” Flanagan added in a CHOP news release.
During the interviews, four distinct themes surfaced:
- The caliber of police officer education
- Inappropriate police enforcement of typical autistic behaviors
- The overt threat of injury and death
- Families believe that police officers may become aggressive towards gestures and responses that are normal for AS children but not for other children, as the study indicated.
Some families said that training might make police see these differences in conduct, which should bring about tolerance and perseverance that could enhance the relations between children and the police.
CHOP Researchers Identify Key Ways to Improve Police Interactions with Black Autistic Youthhttps://t.co/8wlvNa0HUu pic.twitter.com/RhpNeYSc0f
— Autism and Friends (@autismtalknd) December 17, 2024
“In this study, we captured rich narratives from stakeholders who have not been represented well in prior research, but whose thoughts and perspectives are critical for knowing how to improve outcomes for Black autistic youth and police,” said senior researcher Julia Parish-Morris, a scientist in the CHOP Center for Autism Research, as reported by HealthDay.
“Our findings suggest that there is a lot of room for growth in training for police officers and that Black parents of Black autistic youth carry hope that outcomes can be improved,” Parish-Morris added.
News
AI Breakthrough Simplifies Lung Disease Testing
This AI breakthrough promises faster, more accessible, and cost-effective COPD diagnosis with a single CT scan.
United States: Research says that people with breathing problems can know whether they are suffering from COPD with the help of a new lung AI test.
AI Offers a One-Scan Solution for COPD
The newly developed AI can accurately diagnose COPD using data from a single chest CT scan performed as a person inhales, researchers reported Dec. 12 in the journal Radiology: Cardiothoracic Imaging, as reported by HealthDay.
The researchers said it can also inform from that scan how severe a person’s COPD is.
So far, doctors have required two CT scans to diagnose and assess COPD — one when the person has taken a deep breath and one when he or she has exhaled.
“Our study shows that COPD diagnosis and staging is feasible with a single CT acquisition and relevant clinical data,” said researcher Kyle Hasenstab, an assistant statistics and data science professor at San Diego State University.
A Growing Global Health Concern
COPD is defined as a systemic group of lung diseases that become worse over time and make it difficult for individuals in the community to breathe. COPD is chronic, and there is no known treatment for the disease, although it ranks third in deaths globally, according to the researchers’ background information.
The researchers added that spirometry, a lung function test that tests the amount of air, including vital capacity, that a patient can inhale and exhale, has been the primary approach toward identifying COPD.
Some hospitals already use CT images of the lungs to help diagnose COPD because the images can point out lung tissue that might be limiting breath, Hasenstab said.
“However, this type of protocol is not clinically standard across institutions,” Hasenstab said; this is due to the fact that it requires additional training for the staff to be able to take good CT images as well as to be able to interpret them.
Scientists believed that if the AI could read CT scans for COPD, more people could be provided with CT scans, despite a lack of training.
How the AI Works
To provide answers for this study, the researchers captured the inhaled and expelled lung CT scans of nearly 8,900 patients who were tested from November 2007 to April 2011 and their spirometry results.
The average age of patients was 59, and all patients were smokers.
Benefits of the AI Tool
The team then utilized the CT scans and the clinical data to teach the AI to forecast spirometry outcomes.
Study findings indicated that the AI could identify COPD by relying on one of the CT scans and could reasonably express how severe the COPD had become.
Researchers pointed out that when they introduced clinical data, the accuracy of the AI was enhanced.
Researchers also discovered that the AI’s performance was similar when the patients had to hold their breath during the CT scan or when they were breathing normally, as reported by HealthDay.
“Reduction to a single inspiratory CT acquisition can increase accessibility to this diagnostic approach while reducing patient cost, discomfort, and exposure to ionizing radiation,” Hasenstab said in a journal news release.
News
Screen Time Wrecks Preschoolers’ Sleep and Behavior
Excessive screen time disrupts preschoolers’ sleep and behavior, underscoring the need for controlled device usage and better sleep habits.
United States: Excessive use of electronic devices threatens preschoolers’ sleep and urges the child to become a terror of the house, new research shows.
Screen Time and Sleep: A Vicious Cycle
Researchers said poor sleep worsens children’s ability to focus and be less hyperactive and moody, as published in Early Child Development and Care on 12th December.
Worse still, cylinders can occur where kids spend a lot of time in front of screens, leading to poor sleeping habits and consequently increased screen time, as reported hy HealthDay.
“Our results suggest the presence of a positive feedback loop, wherein increased screen time and sleep disturbances exacerbate each other through cyclic reinforcement, heightening the risk of hyperactive attention problems, anxiety, and depression,” said researcher Dr. Bowen Xiao, an expert in children’s socio-emotional functioning and developmental psychopathology with Carleton University in Canada.
The Research: Insights from Parents
To gather data, the authors administered questionnaires to the 571 mothers of preschool children aged between 3 and 6 years attending seven public kindergartens in Shanghai.
Moms recorded the number of daily hours their children spent with a TV, smartphone, computer, or any other screen-based device. They also asked them questions to determine any possible behavioral issues that their kids may have, as well as the quality and duration of sleep their children get.
“Our results indicate that excessive screen time can leave the brains of preschool children in an excited state, leading to poor sleep quality and duration,” said researcher Yan Li, an expert in preschool education from Shanghai Normal University.
Researchers also pointed out that other studies have shown that children’s screen use can cause emotional issues and hyperactivity.
According to this study, screen time may be the cause, according to the experts.
Screen Time’s Impact on Sleep
“This poor sleep may be due to postponed bedtimes caused by screen viewing and the disruption of sleep patterns due to overstimulation and blue-light exposure,” added lead author Shujin Zhou, a doctor of psychology at Shanghai Normal University.
“Screen use might also displace time that could have been spent sleeping and increase levels of physiological and psychological arousal, leading to difficulties in falling asleep,” Zhou said in a journal news release.
Therapeutic Implications
According to Zhou, these findings may help guide future therapies for young children’s mood and hyperactivity issues.
“The implications of our study are two-fold: first, controlling screen use in preschool-age children can help alleviate behavioral problems and poor sleep quality, and second, sleep interventions and treatments can be effective in mitigating the adverse effects of screen time on behavioral issues,” Zhou noted, as reported hy HealthDay.
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