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Hope Rises Against H5N1: Vaccine Development Makes Strides

Groundbreaking mRNA vaccine shows promise in combating H5N1 avian flu outbreaks and revolutionizing flu vaccine production.

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United States: Researchers reveal that an experimental mRNA vaccine against the H5N1 avian flu is highly successful in keeping lab animals from dying or suffering from severe sickness and that seems to be a good sign for the health experts.

Research Insights:

According to researchers, the vaccine may aid in fighting the H5N1 bird flu outbreaks that are currently affecting wild birds, poultry, and cows and also containing those outbreaks is essential to halting the H5N1 virus from spreading to people in United States.

Agility in Vaccine Development

The same methods used to make the COVID vaccinations were also used to create this one.

“We can start creating an mRNA vaccine within hours of sequencing a new viral strain with pandemic potential,” stated senior researcher Scott Hensley, a professor of microbiology at the University of Pennsylvania’s Perelman School of Medicine in Philadelphia. “The mRNA technology allows us to be much more agile in developing vaccines.”

Hensley continued in a university news release, “Vaccines were difficult to manufacture during previous influenza pandemics, like the 2009 H1N1 pandemic, and did not become available until after the initial pandemic waves subsided.”

The majority of flu shots are created with eggs.

In order to facilitate replication, experts inject fertilized chicken eggs with flu strains they anticipate would be the most prevalent and virulent. Next, they render the virus inactive for use in vaccinations.

However, viruses can become adapted to replicate in fertilized eggs over a period of up to six months, which delays production beyond the crucial initial few months of a pandemic.

Director of vaccine research at Penn Medicine Dr. Drew Weissman stated, “Before 2020, experts thought the influenza virus posed the greatest risk of causing a pandemic, and we had limited options for creating a vaccine if that had happened.”

“We are now better prepared to respond to a variety of viruses with pandemic potential, including influenza,” Weissman continued. “COVID-19 showed us the power of mRNA-based vaccines as a tool to protect humans from emerging viruses quickly.”

Targeting H5N1 Subtype

The H5N1 subtype that is primarily circulating in cows and birds is the target of the mRNA vaccine.

People are rarely infected by that type of the virus, researchers are concerned that if it spreads further, it may develop and result in a pandemic of humans and which could be disastrous in the coming future.

In lab mice and ferrets, the experimental vaccine produced a robust immune response, according to research published on May 23 in the journal Nature Communications.

Effective Immune Response in Lab Animals

Additionally, the lab animals retained high antibody levels a year after infection, and animals infected with H5N1 that received vaccinations recovered from the virus more quickly and with fewer side effects than animals who did not receive vaccinations.

Researchers also noted that the efficacy of the mRNA flu vaccine was comparable to that of a vaccine made with conventional egg-based techniques. In lab animals, both vaccinations produced robust antibody responses.

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Bridging the Gap: Police Training for Black Autistic Youth

Improved police training and awareness are essential to ensure safer, more understanding interactions with Black autistic youth.

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Bridging the Gap: Police Training for Black Autistic Youth
Bridging the Gap: Police Training for Black Autistic Youth Credit | Getty images


United States: Black parents with teenagers with autism have concerns about their children’s vulnerability when they encounter police officers.

Key Findings from the Study

A study published on Dec. 16 in the Autism Journal has revealed that aspects like reduced eye contact observed in children with autism may make police consider them to be guilty, as reported by HealthDay.

Sadly, police officers do not learn that these actions are typical among children with autism, families informed scholars.

Voices of the Researchers

“It’s important for everyone to understand that the parents in this study said they were hopeful, which we interpreted as Black caregivers’ faith that interactions between officers and Black autistic youth could be better,” said lead researcher Ashlee Yates Flanagan, a clinical psychologist at the Children’s Hospital of Philadelphia Center (CHOP) for Autism Research.

“This demonstrates that there’s space for improvement in training, and we can take what we know from this study and explore it further,” Flanagan added in a CHOP news release.

During the interviews, four distinct themes surfaced:

  • The caliber of police officer education
  • Inappropriate police enforcement of typical autistic behaviors
  • The overt threat of injury and death
  • Families believe that police officers may become aggressive towards gestures and responses that are normal for AS children but not for other children, as the study indicated.

Some families said that training might make police see these differences in conduct, which should bring about tolerance and perseverance that could enhance the relations between children and the police.

“In this study, we captured rich narratives from stakeholders who have not been represented well in prior research, but whose thoughts and perspectives are critical for knowing how to improve outcomes for Black autistic youth and police,” said senior researcher Julia Parish-Morris, a scientist in the CHOP Center for Autism Research, as reported by HealthDay.

“Our findings suggest that there is a lot of room for growth in training for police officers and that Black parents of Black autistic youth carry hope that outcomes can be improved,” Parish-Morris added.

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AI Breakthrough Simplifies Lung Disease Testing

This AI breakthrough promises faster, more accessible, and cost-effective COPD diagnosis with a single CT scan.

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AI Breakthrough Simplifies Lung Disease Testing
AI Breakthrough Simplifies Lung Disease Testing.


United States: Research says that people with breathing problems can know whether they are suffering from COPD with the help of a new lung AI test.

AI Offers a One-Scan Solution for COPD

The newly developed AI can accurately diagnose COPD using data from a single chest CT scan performed as a person inhales, researchers reported Dec. 12 in the journal Radiology: Cardiothoracic Imaging, as reported by HealthDay.

The researchers said it can also inform from that scan how severe a person’s COPD is.

So far, doctors have required two CT scans to diagnose and assess COPD — one when the person has taken a deep breath and one when he or she has exhaled.

“Our study shows that COPD diagnosis and staging is feasible with a single CT acquisition and relevant clinical data,” said researcher Kyle Hasenstab, an assistant statistics and data science professor at San Diego State University.

A Growing Global Health Concern

COPD is defined as a systemic group of lung diseases that become worse over time and make it difficult for individuals in the community to breathe. COPD is chronic, and there is no known treatment for the disease, although it ranks third in deaths globally, according to the researchers’ background information.

The researchers added that spirometry, a lung function test that tests the amount of air, including vital capacity, that a patient can inhale and exhale, has been the primary approach toward identifying COPD.

Some hospitals already use CT images of the lungs to help diagnose COPD because the images can point out lung tissue that might be limiting breath, Hasenstab said.

“However, this type of protocol is not clinically standard across institutions,” Hasenstab said; this is due to the fact that it requires additional training for the staff to be able to take good CT images as well as to be able to interpret them.

Scientists believed that if the AI could read CT scans for COPD, more people could be provided with CT scans, despite a lack of training.

How the AI Works

To provide answers for this study, the researchers captured the inhaled and expelled lung CT scans of nearly 8,900 patients who were tested from November 2007 to April 2011 and their spirometry results.

The average age of patients was 59, and all patients were smokers.

Benefits of the AI Tool

The team then utilized the CT scans and the clinical data to teach the AI to forecast spirometry outcomes.

Study findings indicated that the AI could identify COPD by relying on one of the CT scans and could reasonably express how severe the COPD had become.

Researchers pointed out that when they introduced clinical data, the accuracy of the AI was enhanced.

Visual Representation.

Researchers also discovered that the AI’s performance was similar when the patients had to hold their breath during the CT scan or when they were breathing normally, as reported by HealthDay.

“Reduction to a single inspiratory CT acquisition can increase accessibility to this diagnostic approach while reducing patient cost, discomfort, and exposure to ionizing radiation,” Hasenstab said in a journal news release.

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Screen Time Wrecks Preschoolers’ Sleep and Behavior

Excessive screen time disrupts preschoolers’ sleep and behavior, underscoring the need for controlled device usage and better sleep habits.

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Screen Time Wrecks Preschoolers’ Sleep and Behavior


United States: Excessive use of electronic devices threatens preschoolers’ sleep and urges the child to become a terror of the house, new research shows.

Screen Time and Sleep: A Vicious Cycle

Researchers said poor sleep worsens children’s ability to focus and be less hyperactive and moody, as published in Early Child Development and Care on 12th December.

Worse still, cylinders can occur where kids spend a lot of time in front of screens, leading to poor sleeping habits and consequently increased screen time, as reported hy HealthDay.

“Our results suggest the presence of a positive feedback loop, wherein increased screen time and sleep disturbances exacerbate each other through cyclic reinforcement, heightening the risk of hyperactive attention problems, anxiety, and depression,” said researcher Dr. Bowen Xiao, an expert in children’s socio-emotional functioning and developmental psychopathology with Carleton University in Canada.

The Research: Insights from Parents

To gather data, the authors administered questionnaires to the 571 mothers of preschool children aged between 3 and 6 years attending seven public kindergartens in Shanghai.

Moms recorded the number of daily hours their children spent with a TV, smartphone, computer, or any other screen-based device. They also asked them questions to determine any possible behavioral issues that their kids may have, as well as the quality and duration of sleep their children get.

“Our results indicate that excessive screen time can leave the brains of preschool children in an excited state, leading to poor sleep quality and duration,” said researcher Yan Li, an expert in preschool education from Shanghai Normal University.

Researchers also pointed out that other studies have shown that children’s screen use can cause emotional issues and hyperactivity.

According to this study, screen time may be the cause, according to the experts.

Screen Time’s Impact on Sleep

“This poor sleep may be due to postponed bedtimes caused by screen viewing and the disruption of sleep patterns due to overstimulation and blue-light exposure,” added lead author Shujin Zhou, a doctor of psychology at Shanghai Normal University.

“Screen use might also displace time that could have been spent sleeping and increase levels of physiological and psychological arousal, leading to difficulties in falling asleep,” Zhou said in a journal news release.

Therapeutic Implications

According to Zhou, these findings may help guide future therapies for young children’s mood and hyperactivity issues.

“The implications of our study are two-fold: first, controlling screen use in preschool-age children can help alleviate behavioral problems and poor sleep quality, and second, sleep interventions and treatments can be effective in mitigating the adverse effects of screen time on behavioral issues,” Zhou noted, as reported hy HealthDay.

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